منابع مشابه
Thiazolidinediones and bone fractures
The topic of increased risk of bone fracture associated with thiazolidinediones (TZD) treatment first drew international attention when a higher rate of fractures in women with diabetes treated with rosiglitazone was reported in the A Diabetes Outcome Program Trial (ADOPT). Subsequently, a number of clinical trials and observational studies addressing this issue have been reported and most of t...
متن کامل[Diabetes mellitus, thiazolidinediones and fractures: an unfinished story].
The association of diabetes mellitus with increased fracture risk is well established, and is observed in both diabetes type 1 and type 2, due to multiple causes. Evidence from rodents suggests that thiazolidinediones (TZD), by activation of PPAR-gamma, cause increased bone marrow adiposity, with decreased osteoblastogenesis resulting in bone loss. Initial studies in humans evidence higher frac...
متن کاملThiazolidinediones and liver toxicity.
Thiazolidinediones or glitazones specifically target insulin resistance. They have proven efficacy for reducing plasma glucose levels of type 2 diabetic patients treated with diet alone, sulphonylureas, metformin or insulin. In addition, they may be associated to some improvement of cardiovascular risk profile. However, troglitazone, the first compound approved by the FDA in the US, proved to b...
متن کاملThiazolidinediones on PPARγ: The Roles in Bone Remodeling
Thiazolidinediones (TZDs) are synthetic PPARγ (peroxisome proliferator-activated receptor gamma) agonists and a class of drugs for diabetes mellitus type 2 that can decrease blood sugar efficiently by enhancing insulin sensitivity. However, increased bone fracture risk in diabetic individuals treated with TZDs is one of the reported side effects. Recent studies show that TZDs such as rosiglitaz...
متن کاملCarpal bone fractures.
Carpal bone fractures make up a significant proportion of injuries to the wrist. The complex bone shape and articulations make diagnosis more difficult and missed injuries more common. This article reviews carpal bone fractures excluding the scaphoid.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Diabetes Investigation
سال: 2011
ISSN: 2040-1116
DOI: 10.1111/j.2040-1124.2011.00142.x